Figure 1. Catestatin (CST) pretreatment (CP) reduced infarct size and maintained cardiac function after cardiac ischemia-reperfusion (I/R) injury in rats.

(a) The procedure of global cardiac I/R (n = 18) and CP (n = 18) and original recording of left ventricular (LV) pressure. (b) The ChgA protein and its cleavage fragments expression were measured by western blot. (c) Heart tissue was stained with triphenyltetrazolium chloride and infarct size (white color) was measured by volume (n = 6 for each group). Evaluation of cardiac function including LV end diastolic pressure (LVEDP)(b), LV developed pressure (dLVP, LV systolic pressure–diastolic pressure) (d), and LV ±dp/dt_max (e) during I/R and CP (total 36 rats were recruited). Data are mean ± SD. *P < 0.05, **P < 0.01 vs I/R group. ^#P < 0.05 vs parameters before ischemia.