Figure 5. CST protected against ER-stress induced apoptosis via ERK1/2 and PI3 K pathway in H9c2 cardiomyoblast.

Western blot analysis of protein expression of ER stress-marker proteins and apoptosis cell number with treatment with stress inducers dithiothreitol (DTT) (a), tunicamycin (b), and thapsigargin (c) after pretreatment with PD98059 or wortmannin. **P < 0.01 vs single ER-stress inducers, ^#P < 0.05 vs single catestatin treatment. Eight independent experiments were performed for above studies.