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. 2015 Nov 12;2(6):e176. doi: 10.1212/NXI.0000000000000176

Figure 2. Baseline immunologic markers are associated with lesion volumes in patients with active disease.

Figure 2

Associations between baseline immunologic markers and lesion volume in the subgroup of patients with active disease (≥1 relapse in the year before baseline). (A) Baseline percentage of CD8+ T cells expressing intracellular IL-22 correlated positively with baseline T2 lesion volume. (B) Baseline percentages of CD8+ cells expressing intracellular IL-17A correlated positively with baseline T2 lesion volume. (C) Baseline percentages of CD8+ cells expressing intracellular IL-17A correlated positively with baseline T1 lesion volume. Fresh peripheral blood mononuclear cells were stimulated with PMA and ionomycin for intracellular cytokine staining. Percentages of cells expressing IL-17A and IL-22 in gated CD4+ and CD8+ T cells were determined by flow cytometry. Statistical analysis was performed using Spearman rank correlation. IL = interleukin; LV = lesion volume.