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. 2015 Nov 16;5:16815. doi: 10.1038/srep16815

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Copyright © 2015, Macmillan Publishers Limited

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(A) The molecular structure of formononetin. (B) Three-dimensional structural models of formononetin fitted into the ligand binding domain (LBD) of ERα. Formononetin was colored pink. Side chains in ERα LBD are colored by atom type (carbon, grey; oxygen, red; hydrogen, blue). (C) In vitro cell-based GeneBLAzer β-lactamase reporter-gene assay showed that formononetin induced the transactivation of ERα significantly. (D) Formononetin showed minimal inhibitory effects on the ERα transactivation induced by17-β-estradiol (E2). Results are presented as mean ± SD (n ≥ 2), p < 0.01.