Fig. 1.
Secretion of PNLIP and p.T221M PNLIP from transfected HEK 293A cells. The media from transfected cells was sampled 72 h after transfection. (A) The lipase activity against tributyrin in 50 μl of medium was measured in the standard 5 minute pH-stat assay. The mean and SD of 3 separate determinations is plotted. (B) The presence of PNLIP was determined by SDS PAGE and protein immunoblot with the rabbit anti-human PNLIP antisera followed by detection with the HRP conjugated goat anti-rabbit IgG antisera. (C) The relative amounts of lipase in the samples were determined by densitometry of 3 separate experiments.