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Emergent substitutions during serial passage in rhesus PBMCs infected with SIVmac239 in the presence of increasing concentrations of INSTIs
| Drug | Result at wk 21–29: |
|
|---|---|---|
| Concn (μM) | Acquired mutations | |
| RAL | 0.1 | None |
| EVG | 0.05 | A54A/V, E92Q, A265A/G, V277V/M |
| DTG | 0.1 | R263K, A54A/V, V277V/M |
