FIG 6.

Measurements of steric allowance provided by topology of the HPV16 capsid. (A) The Fab molecule variable domain (heavy and light chains shown in blue and orange, respectively) was surface rendered at 12-Å resolution and measured through the broadest plane, which was selected empirically when positioned parallel to the contact surface with the HPV16 capsid. (B) On the HPV16 capsid surface (green mesh), the two different potential binding areas between capsomers (red wire) (PDB ID 3J6R) (18) that expose the H16.U4 epitope were defined as area I, bordered by three hexavalent capsomers (black hexagons), and area II that is surrounded by two hexavalent capsomers (black hexagons) and one pentavalent capsomer (black pentagon).