FIG 3.

Endonuclease activities of nairovirus-encoded NPs. (A) Effects of different divalent cations on NP nuclease activities. (B) Time series of in vitro dsDNA degradation assay. (C) Measurement of the specific activities of different NPs. (D) Domains of the CCHFV, HAZV, KUPV, and ERVEV NPs are aligned and shown in the same orientation for comparison. The residues with the most essential impacts on endonuclease activities of nairovirus-encoded NPs are represented as colored sticks, while the polypeptides of the four NPs are displayed as white cartoons.