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Neutralization of primary isolate viruses by 4E10 IgG, WT, and mutant Fabsa
| Antibody | IC50 (nM) |
|||
|---|---|---|---|---|
| Tier 1A (SF162.LS) | Tier 1B (SS1196.1) | Tier 2 (JRCSF) | Control (VSV-G) | |
| 4E10 IgG | 21 | 21 | 20 | >200 |
| 4E10 WT Fab | 146 | 155 | 106 | >200 |
| 4E10 WDWD Fab | >600 | >600 | >600 | >200 |
| 4E10 ΔLoop Fab | >600 | >600 | >600 | >200 |
The data shown are from one of two experiments, both of which gave similar results.
