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Thermodynamic parameters of binding of Fab 4E10 to a 4E10ep varianta
| Fab | ΔGvH (kcal mol−1) | ΔHvH (kcal mol−1) | −TΔSvH (kcal mol−1) | ΔG‡ (kcal mol−1) | ΔH‡ (kcal mol−1) | −TΔS‡ (kcal mol−1) |
|---|---|---|---|---|---|---|
| WT | –10.5 | –11.5 | 1.0 | 11.1 | 29.4 | –18.3 |
| ΔLoop | –10.6 | –12.4 | 1.7 | 11.4 | 25.8 | –14.5 |
| WDWD | –10.1 | –12.6 | 2.5 | 11.2 | 18.6 | –7.4 |
NWFDITNWLWYIR-RRR. “‡” refers to the transition state (see the text).
