FIG 2.
Seroconversion and anti-LPS and anti-FliC IgG geometric mean titers (GMTs) elicited by live oral vaccines CVD 1931 and CVD 1944. Mice (n = 12) were immunized orally with 109 CFU in a 200-μl volume three times (on days 0, 28, and 56 [indicated by arrows]), with 1 month between immunizations. Anti-LPS (A) and anti-FliC (B) serum IgG titers were measured by ELISA pre- and postimmunization (squares, CVD 1931; triangles, CVD 1944; solid symbols, immunized; open symbols, PBS). Titers are expressed as GMTs ± standard errors of the mean (SEM). The percent seroconversion (4-fold increase in titer versus preimmune) is shown. EU, ELISA units.