TABLE 3.

Genes significantly upregulated in infected relative to sham-infected lung tissue^a

Gene product	ST15/4495 infected vs sham infected		ST15/9-47 infected vs sham infected
	Fold gene expression change	Significance	Fold gene expression change	Significance
APCS			5.15	**
C5ar1	14	*	8.47	**
CCL12	36.61	*	15.56	**
CCR5	10.68	*	5.97	**
CD14			61.12	**
CD40	6.21	*	2.55	*
CD86	3.51	*	2.51	**
CSF2			19.34	*
CXCL10			310.55	**
Ddx58			2.36	*
ICAM1	7.91	*	5.13	*
IFN-α2			2.50	*
IFN-β1	96.15	***
IFN-γ	17.2	**	12.25	***
IL-10			17.09	*
IL-1α	29.81	**	16.64	***
IL-1β	88.28	*	52.60	**
IL-1r1	2.1	*
IL-2			4.95	**
IL-23α	40.9	**
IL-6			312.35	**
IRF7	4.01	*	3.80	*
ITGAM	3.73	**
JAK2	3.29	**	4.41	*
Mx1	152.64	*
Myd88	12.3	*	5.22	*
NF-κBIα			20.34	*
NLRP3	36.61	***
Nod2	9	**
SLC11α1	4.26	*	5.25	*
TBX21	2.4	**
TLR3	4.8	**
TLR6			3.84	**
TLR7			4.80	**
TNF	119.21	**	50.78	*
IL-1r1	2.1	*

^aData for genes upregulated significantly after infection with both ear and blood isolates are highlighted in bold type. Statistical significance is indicated as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001 (Student's t-test, two-tailed).