TABLE 2.
Infectivity of wild-type B. burgdorferi (B31-A3) and the ospC mutant in SCID mice using different vehicles and routes of inoculation
| B. burgdorferi strain | Route of inoculationa | Vehicle | No. of infected mice/no. testedb |
|---|---|---|---|
| B31-A3 | i.d. | PBS | 3/3 |
| i.p. | PBS | 3/3 | |
| i.d. | BSK | 3/3 | |
| ospC mutant | i.d. | PBS | 0/3 |
| i.p. | PBS | 0/3 | |
| i.d. | BSK | 0/3 |
a
Spirochetes were inoculated at a dose of 105 either intradermally (i.d.) or intraperitoneally (i.p.).
b
All mice were euthanized at 3 weeks postinoculation. Isolation of spirochetes was attempted from the skin site of inoculation, ear pinna, tibiotarsal joint, heart base, and spleen. Infectivity experiments were conducted two separate times.