TABLE 1.
Genes implicated in altered secreted SpeB protease activity
| Category and gene | Function | Effect of polymorphisms |
|---|---|---|
| Direct transcriptional regulators | ||
| ropB | Transcription factor | Decreased transcription of speB |
| covRS | Two-component system | Decreased transcription of speB |
| ccpA | Transcription factor | Decreased transcription of speB |
| Indirect regulators and posttranscriptional processing | ||
| clpX | ATP-dependent subunit of Clp protease | Decreased transcription and processing |
| fabT | Transcription factor | Decreased transcription and processing |
| luxS | Transcription factor | Decreased transcription and processing |
| pel | Unknown | Decreased transcription and processing |
| sagP | Transcription factor | Decreased transcription and processing |
| Secretion and posttranslational processing | ||
| ftsH | Membrane-associated protease | Decreased maturation of SpeBz to SpeBm |
| gdpP | c-di-AMP phosphodiesterase | Decreased maturation of SpeBz to SpeBm |
| htrA | Periplasm-associated protease | Decreased maturation of SpeBz to SpeBm |
| mtsR | Transcription factor, regulator of prsA | Decreased maturation of SpeBz to SpeBm |
| prsA | Peptidyl-prolyl cis-trans isomerase | Decreased maturation of SpeBz to SpeBm |
| ropA | Peptidyl-prolyl cis-trans isomerase | Decreased maturation of SpeBz to SpeBm |
| Growth phase and environmental signaling | ||
| codY | Transcription factor, growth phase regulation | Increased transcription of speB |
| lacD.1 | Transcription factor, environmental stimuli | Increased transcription of speB |
| nra | Transcription factor, indirect regulator of speB | Increased transcription of speB |
| svr | Transcription factor, growth phase regulation | Increased transcription of speB |
| vfr | Signal peptide for ropB activation | Increased transcription of speB |