FIG 3.

Loss of IFN-γR signaling is associated with greater pulmonary function deficits and increased lung injury. Physiological measurements of lung function in Pneumocystis-infected immune-reconstituted RAG2^−/−, RAG2/IL-4Rα^−/−, and RAG2/IFN-γR^−/− mice were performed. Body weights (A) and respiratory rates (B) were monitored noninvasively over a 27-day period postreconstitution. Specific dynamic lung compliance (C) and lung resistance (D) measurements were performed post-immune reconstitution on anesthetized mice placed in a whole-body plethysmography chamber. Values are means ± 1 standard error (n = 6 to 10 per group at each time point). Data represent results from at least two independent experiments. *, P < 0.05 compared to RAG2^−/− mice; #, P < 0.05 compared to RAG2/IL-4Rα^−/− mice.