FIG 5.

Loss of IFN-γR signaling is associated with increased CD4⁺ T cell-mediated inflammation but decreased lung CD8⁺ T cell responses. BAL fluid cells were collected from immune-reconstituted Pneumocystis-infected RAG2^−/−, RAG2/IL-4Rα^−/−, and RAG2/IFN-γR^−/− mice. Total cells (A), CD4⁺ T cells (B), CD8⁺ T cells (C), and CD8⁺ Foxp3⁺ T cells (D) were enumerated by flow cytometry. Values are means ± 1 standard error (n = 6 to 10 per group at each time point). Data represent results from at least two independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.