TABLE 1.
Average heath index scores and median times to death following PLA2 inhibition in B. anthracis-infected micea
| Treatment | Avg heath index score |
MTD | ||||
|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | ||
| QC ± 5 × 102 spores* | ||||||
| QC only | 0.25 ± 0.00 | 0 | 0 | 0 | 0 | NA |
| 5 × 102 spores only | 0 | 0.20 ± 0.27 | 1.62 ± 0.85 | 3.08 ± 2.45 | 0.50 | 4.0 |
| QC + 5 × 102 spores | 0.70 ± 0.21 | 0.99 ± 0.36 | 2.32 ± 0.29 | 4.38 ± 0.88 | 3.8 | |
| QC(M) + 5 × 102 spores | 1.20 ± 0.21 | 1.59 ± 0.29 | 3.12 ± 0.22 | 4.75 | 3.6 | |
| QC ± 2 × 103 spores* | ||||||
| QC only | 0 | 0 | 0 | 0 | 0 | NA |
| 2 × 103 spores only | 0 | 1.80 ± 0.89 | 3.50 ± 0.90 | 3.25 | 5 | 3.2 |
| QC + 2 × 103 spores | 0.70 ± 0.27 | 2.63 ± 1.30 | 3.25 | 2.2 | ||
| QC(M) + 2 × 103 spores | 0.75 + 0.35 | 2.81 ± 1.60 | 2.3 | |||
| PA ± 2 × 103 spores* | ||||||
| PA only | 0 | 0.20 ± 0.00 | 0.20 ± 0.00 | 0 | 0 | NA |
| 2 × 103 spores only | 0 | 0.37 ± 0.16 | 2.59 ± 0.19 | 3.5 | ||
| PA + 2 × 103 spores | 0 | 0.86 ± 0.12 | 2.57 ± 0.25 | 4.0 | ||
| PA(M) + 2 × 103 spores | 0 | 1.04 ± 0.55 | 2.71 ± 0.14 | 3.5 | ||
a
The table shows average daily health index scores for surviving mice of each group ± standard deviations (SD). *, P < 0.05 by Kruskal-Wallis test comparing the area under the curve (AUC) of daily average health score values for each animal. (M), multiple doses; MTD, median time to death; NA, not applicable.