Daily S/C 25 n mol/kg oxyntomodulin analogue administration increased cumulative 7 day food intake (A) and reduced bodyweight (B) compared to vehicle administration. Average starting weight 506 g. Vehicle, OXM9, OXM10 n = 8/group; all other groups n = 7/group. Data represent mean ± SEM. Significance calculated using one way ANOVA (A, F = 16.78, P < 0.0001; B, F = 5.074, P = 0.0011) with Bonferroni post hoc test (*P < 0.05, ***P < 0.001 vs vehicle controls, ###P < 0.001 vs Exendin-4 group).