Cumulative 7 day food intake (A) and body weight change (B) in response to daily SC injections of various doses of OXM14 or vehicle. Average starting weight 577 g. Vehicle n = 9/group; all other groups n = 8/group. Data represent mean ± SEM. Significance calculated using one way ANOVA (A, F = 4.64, P = 0.0018; B, F = 13.58, P < 0.0001) with Dunnett’s post hoc test (*P < 0.05, ***P < 0.001 vs vehicle controls).