FIGURE 9.
Interactions in the on-copper and off-copper conformations. The active sites of AGAOPEA (A) and the substrate-free and oxidative form of AGAO (Protein Data Bank code 1IU7) (B), in which the TPQ ring has on-copper and off-copper conformations, respectively, are drawn showing hydrogen bonds (dotted lines) and ligation to the copper centers (red lines). Estimated hydrogen bond lengths are shown in Å. The superposition of A and B is shown in C, in which the on-copper (A) and off-copper (B) structures are colored in purple and gray, respectively. All molecular drawings were generated using PyMOL.