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. 2015 Jul 31;290(38):23039–23049. doi: 10.1074/jbc.M115.654962

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Nuclear expression of the calcium buffer parvalbumin regulates dendritic morphology via VEGFD. A, representative micrographs of cultured hippocampal neurons cotransfected with expression vectors for hrGFP and mC.NLS or PV.NLS-mC with or without treatment for 3 days with rVEGFD (100 ng/ml). Scale bar = 20 μm. B, quantification of the total dendritic length of hippocampal neurons transfected as in A and, where indicated, treated with rVEGFD. C, Sholl analysis of hippocampal neurons transfected and treated as indicated. Statistically significant differences were determined by one-way ANOVA followed by Tukey's post hoc test. mC.NLS, PV.NLS-mC, p = 0.001785; mC.NLS + rVEGFD, PV.NLS-mC, p = 0.00472; PV.NLS-mC, PV.NLS-mC + rVEGFD, p = 0.002428. More than 12 neurons from a minimum of three independent preparations were examined for each construct. **, p < 0.01.