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Measured or predicted τc values for CFTR NBD1 ΔRIΔRE
Predicted values were obtained using HydroNMR(47) and the 2PZE structure. Measured values were calculated from observed T1, T2, and heteronuclear NOE values after exclusion of residues with NOE values below 0.6.
| Variant | Sample concentration | τc |
|---|---|---|
| mm | ns | |
| Predicted for monomer | 16–20 | |
| Predicted for dimer | 32–38 | |
| WT | 0.6 | 29.4 ± 2.5 |
| F508del | 0.9 | 19.9 ± 1.1 |
| I539T | 1.5 | 27.3 ± 1.5 |
