FIG 2.

Mapping of recombination breakpoints for sensitive-resistant recombinants. (A) Intrapatient recombination between sensitive and resistant sequences was detected using Recco. The sequenced regions are mapped out relative to the HXB2 reference sequence, with a domain map showing the relative regions. For each sequence listed, the patient name and sequence number are indicated, as well as the day in therapy and R5 resistance, shown in parentheses. The colors indicate the parental sequence, with red indicating R5-resistant sequences and green indicating R5-sensitive sequences, separated by probable breakpoint regions, shown in black. *, sensitive according to unpooled MPI score. (B) Plot indicating the conservation of sensitive (green) and resistant (red) regions in recombinant sequences.