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. 2015 Aug 26;89(22):11275–11283. doi: 10.1128/JVI.01571-15

FIG 4.

FIG 4

Epitope sites do not evolve faster than nonepitope sites. The ratios of the average nonsynonymous substitution rate of epitope sites to that of nonepitope sites are shown. When the substitution rate is computed across the entire tree, the epitope sites always have a lower substitution rate than the nonepitope sites. However, along the trunk of the tree for NP from human influenza virus, the substitution rate in epitopes is slightly higher than the substitution rate at nonepitopes.