FIG 5.

Inhibition of primary HIV isolates in MGBG-treated macrophages. Partially differentiated human macrophages were infected with primary HIV isolate Ba-L, 33931N, or 873 for 2 h, followed by drug treatment for 7 days. Culture supernatant was collected for p24 measurement. EVG was used as a positive control. Drug cytotoxicity was assessed in parallel. The results were normalized against an HIV-infected, nontreated sample in each experiment. IC₅₀s were obtained using the Prism software. The HIV p24 concentrations for the infected, untreated controls were between 2.4 and 4 ng/ml.