FIG 7.

Inhibition of HIV integration by MGBG in both monocytes and macrophages. Isolated human monocytes were either infected immediately with HIV overnight or allowed to differentiate into macrophages prior to viral infection. Cells were cultured for 2 days after infection before being collected for DNA extraction. Drugs were present both during infection and postinfection. The load of total HIV DNA or integrated proviral DNA was determined by qPCR. The graph shows the means, while the dots indicate the actual values from 2 donors, all normalized against the results for the untreated samples.