FIGURE 2.

Docking of OBD into major and minor grooves. A, details of complex B showing OBD1 (green) and OBD2 (pale green) binding mode with loops L_DB docking into contiguous major grooves and α-helix D docking into minor grooves. OBD1 binds to repeats 1 (red) and 2 (orange), and OBD2 binds to repeats 2 and 3 (pink). B, view 90° from A showing that although the OBD2 loop L_DB docks into major groove, helix D from OBD1 binds the minor groove in the opposite face of DNA. C, view 180° from A, showing that only the N-terminal tip of helix D docks into the minor groove.