Pyruvate supplementation partially restores mitochondrial respiration in 293AtNDT2 cells.
A, mitochondrial respiration was assessed by measuring OCR in 293 and 293AtNDT2 cells incubated in the absence (−Pyr) or presence (+2 mm Pyr) of pyruvate, after pyruvate starvation. The figure shows results from a representative experiment. *, p < 0.05. B, quantification of the relative pyruvate-dependent induction of basal and maximal respiration (respiratory capacity) in 293 and 293AtNDT2 cells. n.i., no induction.