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. 2015 Sep 30;290(46):27680–27687. doi: 10.1074/jbc.M115.656173

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — DISC1 knockdown reduces mIPSC amplitude and GABA_AR current density in cultured cortical pyramidal neurons. A, cumulative plots of mIPSC amplitudes in neurons transfected with control shRNA, DISC1 shRNA, or DISC1 shRNA plus an shRNA-resistant full-length DISC1 (DISC1^R). Note that DISC1 knockdown caused a leftward shift in the distribution of mIPSC amplitudes, indicative of a reduction of mIPSC sizes. B, representative mIPSC traces taken from neurons in A. C, summary (mean ± S.E.) of mIPSC amplitudes and frequencies in neurons with different transfections. **, p < 0.01; Dunnett test. con, control. D, representative whole-cell GABA_AR current traces in neurons transfected with control or DISC1 shRNA. E, summary (mean ± S.E.) of GABA_AR current density in neurons with different transfections. *, p < 0.05, Student's t test.