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. 2015 Sep 30;290(46):27680–27687. doi: 10.1074/jbc.M115.656173

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — DISC1 overexpression increases mIPSC amplitude and GABA_AR current density in cultured cortical pyramidal neurons. A, cumulative plots of mIPSC amplitudes in neurons transfected with GFP or FL-DISC1. Note that DISC1 overexpression caused a rightward shift in the distribution of mIPSC amplitudes, indicative of an increase in the sizes of mIPSCs. Inset, representative mIPSC traces. B, summary (mean ± S.E.) of mIPSC amplitudes and frequencies in neurons with different transfections. *, p < 0.05; Student's t test. C, representative whole-cell GABA_AR current traces in neurons transfected with GFP or FL-DISC1. D, summary (mean ± S.E.) of GABA_AR current density in neurons with different transfections. *, p < 0.05; Student's t test.