Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 30;290(46):27680–27687. doi: 10.1074/jbc.M115.656173

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 4. — DISC1 regulation of synaptic inhibition requires KIF5. A, cumulative plots of mIPSC amplitudes in cultured cortical pyramidal neurons transfected with control or KLC1 siRNA. Note that KLC1 knockdown caused a leftward shift in the distribution of mIPSC amplitudes, indicative of a reduction of mIPSC sizes. B and C, cumulative plots of mIPSC amplitudes in neurons transfected with control (con) or DISC1 shRNA in the presence of KLC1 siRNA (B) or dominant-negative (DN) KIF5C (C). E, cumulative plots of mIPSC amplitudes in neurons with or without FL-DISC1 transfection in the presence of DN-KIF5C. Insets (A–C and E), representative mIPSC traces. D and F, summary (mean ± S.E.) of mIPSC amplitudes in neurons with different transfections. *, p < 0.05; **, p < 0.01; NS, not significant; analysis of variance.