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The model depicts transcriptionally silent chromatin with unmodified histone H1 in the absence of AhR-KLF6 binding to the NC-XRE. AhR-KLF6 DNA binding and CPS1 recruitment results in localized synthesis of carbamoyl phosphate and histone H1 homocitrullination (H1K34hcit) through a nonenzymatic process, shifting chromatin into an active conformation.
