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Donor saturation assay analyzed by BRET for the WT PRKAR1A and the variants carrying mutations at positions Ala-213 and Gly-289 associated with acrodysostosis and the Carney complex. The specific interaction between the catalytic and regulatory subunits is identified by a hyberbolic increase of the BRET expressed as a percentage of maximal BRET (y) as a function of increases in the YFP/luciferase ratio (x).
