TABLE III.

Targeted Toxicities in Each of Four Treatment Periods

Period	Toxicity	Gradea
		0	1	2	3
1	Gastritis	55	0	2	0
	Vomiting	42	10	4	1
	Hemorrhage, GI—abdomen NOS	56	1	0	0
	Hemorrhage, other	56	1	0	0
	Ocular, other	54	3	0	0
	Pain—abdomen NOS	43	10	2	2
	Pain—head/headache	49	3	4	1
	Thrombosis/thrombus/embolism	57	0	0	0
2	Gastritis	35	0	1	0
	Vomiting	35	1	0	0
	Hemorrhage, GI—abdomen NOS	36	0	0	0
	Hemorrhage, other	36	0	0	0
	Ocular, other	34	2	0	0
	Pain—abdomen NOS	27	7	2	0
	Pain—head/headache	34	0	2	0
	Thrombosis/thrombus/embolism	36	0	0	0
3	Gastritis	27	0	0	0
	Vomiting	25	0	2	0
	Hemorrhage, GI—abdomen NOS	27	0	0	0
	Hemorrhage, other	27	0	0	0
	Ocular, other	26	1	0	0
	Pain—abdomen NOS	23	2	1	1
	Pain—head/headache	24	1	2	0
	Thrombosis/thrombus/embolism	27	0	0	0
4	Gastritis	16	0	1	0
	Vomiting	15	1	1	0
	Hemorrhage, GI—abdomen NOS	17	0	0	0
	Hemorrhage, other	16	1	0	0
	Ocular, other	17	0	0	0
	Pain—abdomen NOS	13	0	2	2
	Pain—head/headache	13	2	1	1
	Thrombosis/thrombus/embolism	17	0	0	0

GI, gastrointestinal; NOS, not otherwise specified.

^aNote that no Grade 4 or 5 targeted toxicities were observed.