TABLE III.
Targeted Toxicities in Each of Four Treatment Periods
| Period | Toxicity | Gradea | |||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | ||
| 1 | Gastritis | 55 | 0 | 2 | 0 |
| Vomiting | 42 | 10 | 4 | 1 | |
| Hemorrhage, GI—abdomen NOS | 56 | 1 | 0 | 0 | |
| Hemorrhage, other | 56 | 1 | 0 | 0 | |
| Ocular, other | 54 | 3 | 0 | 0 | |
| Pain—abdomen NOS | 43 | 10 | 2 | 2 | |
| Pain—head/headache | 49 | 3 | 4 | 1 | |
| Thrombosis/thrombus/embolism | 57 | 0 | 0 | 0 | |
| 2 | Gastritis | 35 | 0 | 1 | 0 |
| Vomiting | 35 | 1 | 0 | 0 | |
| Hemorrhage, GI—abdomen NOS | 36 | 0 | 0 | 0 | |
| Hemorrhage, other | 36 | 0 | 0 | 0 | |
| Ocular, other | 34 | 2 | 0 | 0 | |
| Pain—abdomen NOS | 27 | 7 | 2 | 0 | |
| Pain—head/headache | 34 | 0 | 2 | 0 | |
| Thrombosis/thrombus/embolism | 36 | 0 | 0 | 0 | |
| 3 | Gastritis | 27 | 0 | 0 | 0 |
| Vomiting | 25 | 0 | 2 | 0 | |
| Hemorrhage, GI—abdomen NOS | 27 | 0 | 0 | 0 | |
| Hemorrhage, other | 27 | 0 | 0 | 0 | |
| Ocular, other | 26 | 1 | 0 | 0 | |
| Pain—abdomen NOS | 23 | 2 | 1 | 1 | |
| Pain—head/headache | 24 | 1 | 2 | 0 | |
| Thrombosis/thrombus/embolism | 27 | 0 | 0 | 0 | |
| 4 | Gastritis | 16 | 0 | 1 | 0 |
| Vomiting | 15 | 1 | 1 | 0 | |
| Hemorrhage, GI—abdomen NOS | 17 | 0 | 0 | 0 | |
| Hemorrhage, other | 16 | 1 | 0 | 0 | |
| Ocular, other | 17 | 0 | 0 | 0 | |
| Pain—abdomen NOS | 13 | 0 | 2 | 2 | |
| Pain—head/headache | 13 | 2 | 1 | 1 | |
| Thrombosis/thrombus/embolism | 17 | 0 | 0 | 0 | |
GI, gastrointestinal; NOS, not otherwise specified.
a
Note that no Grade 4 or 5 targeted toxicities were observed.