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. Author manuscript; available in PMC: 2015 Nov 16.
Published in final edited form as: Periodontol 2000. 2015 Jun;68(1):66–82. doi: 10.1111/prd.12052

Fig. 1.

Fig. 1

Rabbit as a model for periodontal disease. In New Zealand White rabbit, periodontal disease can be established by placing silk ligatures around the second premolars. The rabbit oral microbiota does not result in periodontal disease development upon accumulation around the ligatures. A pathogenic bacterium (e.g. Porphyromonas gingivalis) can be applied throughout the study (6 weeks). Clinical, radiographic and histologic evidence demonstrate clear periodontal tissue destruction, similar to the disease process in humans. Established periodontal disease in rabbits is not reversible when left untreated (68). CFU, colony-forming units.