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. Author manuscript; available in PMC: 2016 Jul 17.
Published in final edited form as: J Mol Biol. 2015 May 21;427(14):2379–2395. doi: 10.1016/j.jmb.2015.05.012

Fig. 4.

Fig. 4

Dissection of the TOG domains. (a) Structural alignment of HRs. Structures of HR1-5 from hC2-TOG2 (green), mC2-TOG3 (blue) and Stu2-TOG1 (pink) are superimposed using the main-chain Cα atoms of 15 residues in the B helix of each HR. The secondary structure is defined using DSSP [53]. The side chains of the residues involved in tubulin recognition are shown and labeled. (b) Superposition of hC2-TOG2 (green), mC2-TOG3 (blue) and Stu2-TOG1 (pink). Structures are superimposed using the B helices of HR1-3. The curvature was defined as the angle between two vectors connecting the N-terminal Cα atoms of H4B and H5B. The Cα atoms used for creating these vectors are indicated with spheres.