Table.

GRADE Evaluation of interventions for Tubal ectopic pregnancy.

Important outcomes	Subsequent pregnancy
Studies (Participants)	Outcome	Comparison	Type of evidence	Quality	Consistency	Directness	Effect size	GRADE	Comment
What are the effects of treatments for unruptured tubal ectopic pregnancy on subsequent fertility?
5 (295)	Subsequent pregnancy	Methotrexate (single or multiple dose) versus salpingotomy	4	–1	0	0	0	Moderate	Quality point deducted for early termination of planned recruitment in 1 RCT
1 (446)	Subsequent pregnancy	Salpingectomy versus salpingotomy	4	–1	0	0	0	Moderate	Quality point deducted for incomplete reporting of results
2 (127)	Subsequent pregnancy	Salpingotomy by laparoscopy versus salpingotomy by laparotomy	4	–1	0	0	0	Moderate	Quality point deducted for sparse data

We initially allocate 4 points to evidence from RCTs, and 2 points to evidence from observational studies. To attain the final GRADE score for a given comparison, points are deducted or added from this initial score based on preset criteria relating to the categories of quality, directness, consistency, and effect size. Quality: based on issues affecting methodological rigour (e.g., incomplete reporting of results, quasi-randomisation, sparse data [<200 people in the analysis]). Consistency: based on similarity of results across studies. Directness: based on generalisability of population or outcomes. Effect size: based on magnitude of effect as measured by statistics such as relative risk, odds ratio, or hazard ratio.