Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Subsequent intrauterine pregnancy
Systematic review	Haemodynamically stable women, each with small unruptured tubal pregnancy 3 RCTs in this analysis	Subsequent intrauterine pregnancy rates 18/40 (45%) with single-dose methotrexate (intramuscular) 29/58 (50%) with salpingotomy (by laparoscopy)	RR 1.01 95% CI 0.66 to 1.54		Not significant
Systematic review	74 haemodynamically stable women, each with a laparoscopically confirmed unruptured tubal pregnancy Data from 1 RCT	Subsequent intrauterine pregnancy rates 12/34 (35%) with multiple-dose methotrexate (intramuscular) 16/40 (40%) with salpingotomy (by laparoscopy)	RR 0.88 95% CI 0.49 to 1.60		Not significant
RCT	106 women with ectopic pregnancy	Cumulative rates of spontaneous intrauterine pregnancy with single-dose methotrexate with laparoscopic salpingotomy Absolute results reported graphically	HR 1.41 95% CI 0.88 to 2.26 P = 0.15 Study was underpowered; see Further information on studies		Not significant