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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Endocr Relat Cancer. 2015 Aug 18;22(6):T209–T220. doi: 10.1530/ERC-15-0217

Figure 1. Genomic organization of the AR gene and overall domain structure of the AR protein.

Figure 1

The AR gene is mapped to the long arm of X chromosome and spans about 186.5 kb. It contains eight exons interrupted by introns of various lengths (indicated below). The mRNA of AR gene is of 10.6 kb with exon 1 coding for the NTD, exons 2 and 3 the DBD, exons 4-8 the hinge and LBD. The full length AR protein contains 919 amino acids, consisting of a very flexible NTD and constant DBD, hinge domain and LBD. The constitutively active AF1 domain is located in the NTD and the LBD consists of the AF2 domain.