TABLE 2.

PEDF orthologue alignment

Accession number	Class	Order	Species	Protein	Starting amino acid	Sequencea	Ending amino acid
AAA84914	Mammalia	Primates	Human	PEDF	71	QRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASR	141
XP_003816903	Mammalia	Primates	Bonobo	PEDF	71	QRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASR	141
XP_001155004	Mammalia	Primates	Chimpanzee	PEDF	71	QRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASR	141
XP_002747873	Mammalia	Primates	Marmoset	PEDF	71	QRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLRSASR	141
EHH24345	Mammalia	Primates	Rhesus monkey	PEDF	71	QRTESVIHRALYYDLISSPDIHGTYKELLGTVTAPQKNLKSASR	141
XP_003799139	Mammalia	Primates	Small eared galago	PEDF	71	QQTESVIHRALYYDLINNPDIHGTYKELLATVTDAQKNFKSASR	141
XP_002826865	Mammalia	Primates	Sumatran orangutan	PEDF	71	QRTESTIHRALYYDLISSPDIHGTYKELLDTVTAPQKNFKSASR	141
NP_001072130	Mammalia	Cetartiodactyla	Boar	PEDF	69	QRTESSLHRALYYDLISNPDLHGTYKELLAAVTAPQKNLKSASR	139
XP_003515170	Mammalia	Rodentia	Chinese hamster	PEDF	72	QRTESIIHRALYYDLISNSDIHSTYKELLASVTAPEKSLKSASR	142
NP_776565	Mammalia	Artiodactyla	Cow	PEDF	69	QRTESNIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASR	139
NP_001071056	Mammalia	Carnivora	Dog	PEDF	49	QRTESTIHRALYYDLISNPDIHSTYKELLASVTAPEKNFKSASR	119
XP_003417025	Mammalia	Proboscidea	Elephant	PEDF	70	QRTESTIHRALYYDLISIADIHDTYKELLAAVTAPEKNLKSASR	140
AES06342	Mammalia	Carnivora	Ferret	PEDF	71	QRTESTIHRALYYDLISNPDIHGTYKELLAAVTAPEKNFKSASR	141
NP_001166531	Mammalia	Rodentia	Guinea pig	PEDF	70	QRTEATIHRALYYDMISNPDIHSTYKELLATVTAPQKNLKSASR	140
NP_001137426	Mammalia	Perissodactyla	Horse	PEDF	71	QRTESSIHLALYYDLIKNPDIHGTYKELLASVTAPNKNFKSASR	141
CAX15544	Mammalia	Rodentia	Mouse	PEDF	70	HRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASR	140
EHB07111	Mammalia	Rodentia	Naked mole rat	PEDF	70	QRTESIIHRALYYDVISNPDIHGTYKELLATVTGPQKNLKSASR	140
XP_001371584	Mammalia	Didelphimorphia	Opossum	PEDF	69	PKTQSTIHRALYYDLITNQDIHSTYKELLATVTAAQKNLKSASR	139
XP_001507178	Mammalia	Monotremata	Platypus	PEDF	70	PRTESLIHRALYYDLIHNPDIHGTYKELLATVTAPQKNLKTASR	140
EDM05207	Mammalia	Rodentia	Rat	PEDF	49	QRTESVIHRALYYDLINNPDIHSTYKELLASVTAPEKNFKSASR	119
NP_001132919	Mammalia	Artiodactyla	Sheep	PEDF	69	QRTESSIHRALYYDLISNPDIHGTYKDLLASVTAPQKNLKSASR	139
XP_003770166	Mammalia	Dasyuromorphia	Tasmanian devil	PEDF	72	QRTESTIHRALYYDLITNPDIHGTYKELLASVTASQKNLKSASR	142
NP_035470	Mammalia	Rodentia	Mouse	PEDF	70	HRTESVIHRALYYDLITNPDIHSTYKELLASVTAPEKNLKSASR	140
XP_002918078	Mammalia	Carnivora	Panda	PEDF	71	QRTETTIHRALYYDLITNPDIHGTYKELLASVTAPEKNFKSASR	141
XP_003226635	Reptilia	Squama	Carolina anole	PEDF	263	ERTEDTIQRALFYDLLDKAQVHEVYKGLLGSLTGPAKAFKTAAR	333
AAZ22323	Actinopterygii	Pleuronectiformes	Japanese flounder	PEDF	60	ELAERQLFRALRFHTLQDPQLHNTLKDLLASLRSPGKGLSIAAR	130
XP_003457710	Actinopterygii	Perciformes	Tilapia	PEDF	83	EHAQRQLYRALRYHTLQDPQLHNTLKDMLASVRTAGKGLSTAAR	153
NP_001004539	Actinopterygii	Cypriniformes	Zebrafish	PEDF	61	ERAEKQIYRALRYHTLQDSQLHDTLRDLLSSLRASAKGFKSAER	131
NP_001133806	Actinopterygii	Salmoniformes	Atlantic salmon	PEDF precursor	61	DRSERWLYRALRYHTLQDPQLHDTLRDLLASLRAPGKGLSIAAR	132
NP_001085983	Amphibia	Anura	African clawed frog	PEDF	61	QRTESLIHRSLYYDLLNDPELHATYKELLASLTSHGSGLKSTWR	131
NP_989086	Amphibia	Batrachia	Western clawed frog	PEDF	61	QRTESLIQRSLYYDLLNDPEVHATYKDLLASFTSQASGLKSTWR	131
NP_001244218	Aves	Galliformes	Chicken	PEDF	69	ERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASR	139
XP_003211790	Aves	Galliformes	Turkey	PEDF	69	ERTEDVISRALFYDLLNKAEVHNTYKDLLASVTGPEKSLKSASR	139
XP_002197455	Aves	Neognathae	Zebra finch	PEDF	38	ERTEDVISRALFYDLLNKAEVHDTYKELLSSVTGPEKSMKSASR	108

^a Position Arg⁹⁹ of human PEDF and aligned positions are highlighted.