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. 2015 Aug 20;290(42):25322–25332. doi: 10.1074/jbc.M115.645234

FIGURE 4.

FIGURE 4.

Selective binding of hMincle to cholesterol crystals. A, reporter cells expressing mMincle, hMincle, mouse MCL (mMCL), or human MCL (hMCL) were stimulated, and the NFAT-GFP induction was analyzed by flow cytometry. B, reporter cells expressing the indicated CLRs were co-cultured with cholesterol crystals for 18 h. C, reporter cells expressing FcRγ together with human, mouse, or rat Mincle were stimulated with cholesterol crystals for 18 h. The NFAT-GFP induction was analyzed by flow cytometry. All data are representative of three separate experiments and presented as mean ± S.D. *, p < 0.05.