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. 2015 Sep 4;290(42):25595–25608. doi: 10.1074/jbc.M115.661413

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Increased phospho-HLXB9, decreased Cblb, and increased c-Met in insulinoma from the conventional mouse model of menin loss (Men1^+/−). Shown are images of immunofluorescence for insulin and IHC for the indicated proteins in the pancreas section of an 18-month-old Men1^+/− mouse. Insulin staining shows the location of the normal-looking islet (panels on the left) and the large islet tumor that covers the entire viewing field (panels on the right). Compared with a normal-looking insulin-positive islet in the same section, the insulin-positive islet tumor shows increased nuclear staining for HB9 and HB9-PO4 and increased nuclear and cytoplasmic staining for c-Met but almost no staining for Cblb (cytoplasm).