FIGURE 8.
Increased phospho-HLXB9, decreased Cblb, and increased c-Met in insulinoma from the conditional mouse model of menin loss (RIP-Cre-Men1f/f). Images of immunofluorescence for insulin and IHC for the indicated proteins in pancreas sections from a 12-month-old Men1f/f mouse and RIP-Cre-Men1f/f mouse. Compared with the insulin-positive normal islet (panels on the left), the large insulin-positive islet tumor that covers the entire viewing field (panels on the right) shows increased nuclear staining for HB9 and HB9-PO4, increased nuclear and cytoplasmic staining for c-Met, and decreased staining for Cblb (cytoplasm).