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Interactions of rosiglitazone, 15d-PGJ2, GW0742, and J11-Cl with the ligand binding domain of either PPARγ or PPARβ/δ. A, docking simulation of J11-Cl to the ligand binding domain of PPARγ. B, cocrystal structure of 15d-PGJ2 with PPARγ (PDB code number 2ZK1). C, cocrystal structure of rosiglitazone with PPARγ (PDB code number 2PRG). D, docking simulation of J11-Cl to the ligand binding domain of PPARβ/δ. E, cocrystal structure of GW0742 with PPARβ/δ (PDB code number 3TKM).
