FIGURE 3.

J11-Cl significantly increased survival of mice and alleviated symptoms of colitis. Mice were supplied with 3% DSS in drinking water for 11 days. One group of mice was treated with J11-Cl (50 mg·kg⁻¹) and the other group of mice was treated with vehicle (1% DMSO and 5% cremophor in saline) daily by intraperitoneal injection. The mice were monitored for rectal bleeding and diarrhea (scaled 0–4) for the duration of the experiment. A, analysis of survival rate using the log-rank test indicated that J11-Cl significantly increased survival of mice (p = 0.0013). B, body weight loss in mice treated with J11-Cl was less severe than that in the control group (vehicle treated mice). C, rectal bleeding was relieved by J11-Cl compared with the control group. D, diarrhea was relieved by J11-Cl compared with the control group. Data are shown as the mean ± S.E.; n = 12 (control group), n = 14 (J11-Cl group). A single asterisk (*) indicates p < 0.05; double asterisks (**) indicate p < 0.01; triple asterisks (***) indicate p < 0.001.