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S1-P1 interactions in the tPA·PAI-1 Michaelis complex structure show interactions in the S1 pocket different from those in the uPA·PAI-1 Michaelis complex structure (PDB code 3PB1). A, interactions between PAI-1 P1 Arg and tPA. B, interactions between PAI-1 P1 Arg and uPA. There is one residue difference between tPA and uPA (Ala-190 and Ser-190, respectively).
