FIGURE 1.

Hepatic CREB and CRTC2 are active under fasting conditions. a, immunoblot showing hepatic CREB (phosphorylated and total) under fasting and refed conditions in STZ treated and control mice. b, relative expression of PCK1 and G6Pase in livers of fasted and refed STZ and control animals. Expression levels are normalized to L32 and expressed as fold change to control fasted mice, n = 3. c, ChIP assay of CRTC2 over PCK1 and G6Pase promoters in livers from STZ or control mice under fasted and refed conditions; ChIP signals are normalized to total input.