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. 2015 Sep 4;290(43):25997–26006. doi: 10.1074/jbc.M115.679266

FIGURE 4.

FIGURE 4.

Chronic activation of the CREB pathway in liver increases fasting blood glucose concentrations. a, average overnight fasting blood glucose levels of mice infected with AAV.Empty or AAV.CRTC2AA over a 37-day period, n = 10. b, average blood glucose levels during ad-lib and fasting conditions; day 17–30, n = 10–20. c, pyruvate tolerance test on day 20 post virus injection, 2 g sodium pyruvate/kg mouse, n = 7. Right hand side of the figure shows calculated total area under the curve and incremental area under the curve. d, intraperitoneal glucose tolerance test on day 10 following viral infection, 1 g glucose/kg mouse, n = 10. Right, calculated total and incremental area under the curve. e, continuous glucose monitoring over a 24 h light/dark cycle with free access to food and water; n = 2 per group, 2 days of monitoring; average values shown. (*, p < 0.05; **, p < 0.005; ***, p < 0.0005 compared with AAV.Empty mice; data shown as mean ± S.E.).