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. 2015 Sep 8;290(43):26194–26203. doi: 10.1074/jbc.M115.678979

FIGURE 3.

FIGURE 3.

VEGF-A production by CRH and Ucn 3 is cAMP-dependent. cAMP EIA was monitored in NCM460 cells expressing an empty vector (EV) (A) or CRHR1 (B) or CRHR2 (C). VEGF-A ELISA was performed in NCM460 cells (D) or NCM460 cells expressing CRHR1 or CRHR2 (E) after adding 8-bromo-cAMP exogenously. In the presence of adenylyl cyclase inhibitor SQ22536, VEGF-A ELISA was performed in NCM460 cells (F) or NCM460 cells expressing CRHR1 (G) or CRHR2 (H). Data are mean ± S.D. *, p < 0.05 versus vehicle; #, p < 0.05 versus CRH; $, p < 0.05 versus Ucn 3.